Articolo del mese Settembre 2016

Diabetology & Metabolic Syndrome: The impact of the metabolic phenotype on thyroid function in obesity
Paolo Marzullo1,4*, Chiara Mele1,4, Stefania Mai2, Gabriele Guzzaloni1, Davide Soranna3, Maria Antonella Tagliaferri1, Maria Elisa Berselli1, Flavia Prodam4, Daniela Surico5, Gianluca Aimaretti4 and Massimo Scacchi1,6

Marzullo et al. Diabetol Metab Syndr (2016) 8:59 DOI 10.1186/s13098-016-0177-x

Materials and methods: BIA 101 Impedance Analyser - Akern

Obesity is known to promote mild hyperthyrotropinaemia by unknown metabolic mechanisms. This investigation aimed to explore the association between thyroid function and metabolic phenotype in euthyroid obese individuals. Retrospective, cross-sectional study. Tertiary care center.

952 euthyroid obese individuals referred to our Institution for obesity. Serum levels of TSH, FT4, glucose, insulin and HbA1c levels, lipid profile, liver function and proinflammatory indices were measured. Resting energy expenditure was assessed by indirect calorimetry and body composition by bioimpedance analysis. Authors conclude that in euthyroid obese subjects, FT4 seems more closely related than TSH levels to parameters of cardio-metabolic risk. TSH levels did not differ between metformin-treated and untreated subjects, while they were lower in patients with incident diabetes mellitus compared to normoglycaemic ones.

Article available on Springerlink DOI 10.1186/s13098-016-0177-x – published online August 24 2016